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An overview of the implantation areas in all study groups at day 10 post-implantation and the tissue reactions to the BBS granules. BBS = granules of the biphasic bone substitute, LB = local bone, CT = connective tissue, red stars = newly formed bone matrix, red arrows = blood vessels, white arrows = new material-related bone, black arrows = macrophages, yellow arrowheads = multinucleated giant cells, blue arrows = <t>osteoblasts</t> (Movat Pentachrome-stainings, (A1–C1) , ×100 magnification, scale bar = 50 μm; (A2–C2) , ×200 magnification, scale bar = 20 µm).
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An overview of the implantation areas in all study groups at day 10 post-implantation and the tissue reactions to the BBS granules. BBS = granules of the biphasic bone substitute, LB = local bone, CT = connective tissue, red stars = newly formed bone matrix, red arrows = blood vessels, white arrows = new material-related bone, black arrows = macrophages, yellow arrowheads = multinucleated giant cells, blue arrows = <t>osteoblasts</t> (Movat Pentachrome-stainings, (A1–C1) , ×100 magnification, scale bar = 50 μm; (A2–C2) , ×200 magnification, scale bar = 20 µm).
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normal human osteoblast cells nhost - by Bioz Stars, 2026-08
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An overview of the implantation areas in all study groups at day 10 post-implantation and the tissue reactions to the BBS granules. BBS = granules of the biphasic bone substitute, LB = local bone, CT = connective tissue, red stars = newly formed bone matrix, red arrows = blood vessels, white arrows = new material-related bone, black arrows = macrophages, yellow arrowheads = multinucleated giant cells, blue arrows = osteoblasts (Movat Pentachrome-stainings, (A1–C1) , ×100 magnification, scale bar = 50 μm; (A2–C2) , ×200 magnification, scale bar = 20 µm).

Journal: Frontiers in Bioengineering and Biotechnology

Article Title: Biphasic bone substitutes coated with PLGA incorporating therapeutic ions Sr 2+ and Mg 2+ : cytotoxicity cascade and in vivo response of immune and bone regeneration

doi: 10.3389/fbioe.2024.1408702

Figure Lengend Snippet: An overview of the implantation areas in all study groups at day 10 post-implantation and the tissue reactions to the BBS granules. BBS = granules of the biphasic bone substitute, LB = local bone, CT = connective tissue, red stars = newly formed bone matrix, red arrows = blood vessels, white arrows = new material-related bone, black arrows = macrophages, yellow arrowheads = multinucleated giant cells, blue arrows = osteoblasts (Movat Pentachrome-stainings, (A1–C1) , ×100 magnification, scale bar = 50 μm; (A2–C2) , ×200 magnification, scale bar = 20 µm).

Article Snippet: Primary normal human osteoblasts (NHOst; Lonza) were cultured in OGM (OBM supplemented with OGM Single Quots; Lonza) and grown as monolayer cultures in T75 flasks (Greiner Bio-One).

Techniques:

An overview of the implantation areas in all study groups at day 30 post implantation and the tissue reactions to the bone substitute granules. BBS = granules of the biphasic bone substitute, LB = local bone, CT = connective tissue, red stars = newly formed bone matrix, red arrows = blood vessels, black arrows = macrophages, yellow arrowheads = multinucleated giant cells, blue arrows = osteoblasts (Movat Pentachrome-stainings, (A1–C1) , ×100 magnification, scale bar = 50 μm; (A2–C2) , ×200 magnification, scale bar = 20 µm).

Journal: Frontiers in Bioengineering and Biotechnology

Article Title: Biphasic bone substitutes coated with PLGA incorporating therapeutic ions Sr 2+ and Mg 2+ : cytotoxicity cascade and in vivo response of immune and bone regeneration

doi: 10.3389/fbioe.2024.1408702

Figure Lengend Snippet: An overview of the implantation areas in all study groups at day 30 post implantation and the tissue reactions to the bone substitute granules. BBS = granules of the biphasic bone substitute, LB = local bone, CT = connective tissue, red stars = newly formed bone matrix, red arrows = blood vessels, black arrows = macrophages, yellow arrowheads = multinucleated giant cells, blue arrows = osteoblasts (Movat Pentachrome-stainings, (A1–C1) , ×100 magnification, scale bar = 50 μm; (A2–C2) , ×200 magnification, scale bar = 20 µm).

Article Snippet: Primary normal human osteoblasts (NHOst; Lonza) were cultured in OGM (OBM supplemented with OGM Single Quots; Lonza) and grown as monolayer cultures in T75 flasks (Greiner Bio-One).

Techniques:

An overview of the implantation areas in all groups at day 90 post implantation and the tissue reaction to the bone substitutes granules. BBS = granules of the biphasic bone substitute, LB = local bone, CT = connective tissue, red stars = newly formed bone matrix, red arrows = blood vessels, black arrows = macrophages, yellow arrowheads = multinucleated giant cells, blue arrows = osteoblasts (Movat Pentachrome-stainings, (A1–C1) , ×100 magnification, scale bar = 50 μm; (A2–C2) , ×200 magnification, scale bar = 20 µm).

Journal: Frontiers in Bioengineering and Biotechnology

Article Title: Biphasic bone substitutes coated with PLGA incorporating therapeutic ions Sr 2+ and Mg 2+ : cytotoxicity cascade and in vivo response of immune and bone regeneration

doi: 10.3389/fbioe.2024.1408702

Figure Lengend Snippet: An overview of the implantation areas in all groups at day 90 post implantation and the tissue reaction to the bone substitutes granules. BBS = granules of the biphasic bone substitute, LB = local bone, CT = connective tissue, red stars = newly formed bone matrix, red arrows = blood vessels, black arrows = macrophages, yellow arrowheads = multinucleated giant cells, blue arrows = osteoblasts (Movat Pentachrome-stainings, (A1–C1) , ×100 magnification, scale bar = 50 μm; (A2–C2) , ×200 magnification, scale bar = 20 µm).

Article Snippet: Primary normal human osteoblasts (NHOst; Lonza) were cultured in OGM (OBM supplemented with OGM Single Quots; Lonza) and grown as monolayer cultures in T75 flasks (Greiner Bio-One).

Techniques: